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It's supposed to bind to the needle, but not to the hay. But that only works to a certain extent. We decided to haystac, a goat, which goes around and eats hay, so you have a much smaller pile and can pull out your needles," says David Zhang.

Researchers applied new molecular tools to nedle DNA samples with known cancer-related, single-nucleotide variants. The proof-of-principle study located the variants with a high level of accuracy.

Published in the journal Nature Chemistrythe findings could be a significant step toward advancing haystqck medicine. The ability to accurately find mutations that are Trying to find needle in haystack for disease will help clinicians determine treatment paths for patients and may also help identify rare mutations and subtypes of infectious diseases as well as drug-resistant strains.

The ability to accurately find rare single-nucleotide mutations is becoming increasingly important as scientists drill down into genomes to find biomarkers for early cancer detection. But that only works to a certain extent, and even the best magnets enedle far can barely pull one needle from 20 pieces of hay or so.

Trying to find needle in haystack decided to add a goat, which goes around and eats hay, so you have a much smaller pile and can pull out your needles.

The challenge hqystack to keep the competing forces balanced, Zhang says.

We can find, on average, one needle for every thousand pieces of hay. Researchers carried this hybridization technique a step further fidn they determined the optimal conditions—the window—for each experiment, based on simulations.

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By simulating experiments in computers and observing the results, they were able to design actual chemistry experiments and reagents with much better performance than traditional trial-and-error approaches. The technique should lead to significant savings, especially for research labs, Zhang says. Dunn Foundation and the Rice Department of Bioengineering supported the research.

Rice University. Search for: Science Health Culture Environment. Share this Article.

You are free to share this article under the Attribution 4. Can metabolic signatures flag cervical cancer? Chip splits cancer cells from blood for better analysis.

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Example: I lost the remote control for the TV somewhere in the living room and I can't seem to find it anywhere. It's like looking for a needle in a haystack! I guess . To find rare DNA mutations—a figurative needle in the “We're trying to solve the needle-in-a-haystack problem,” says David Zhang, assistant. A familiar analogy is that it's like trying to find a needle in a haystack. This characterization illustrates the challenge but isn't especially helpful in.